Pawbiotix is formulated with natural, proven ingredients, making it safe for dogs of all ages and sizes. No serious side effects are known with this supplement. However, as with any new product, some dogs may experience temporary digestive discomfort, such as mild cramping or gas, as their system adjusts to the probiotics. This typically resolves as the dog’s body adapts. It’s always advisable to consult with a veterinarian before starting any supplement, especially if your dog has pre-existing health conditions.